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Discussion Starter · #1 ·
Date: Mon, 8 Mar 2004 20:29:54 -0600
Reply-To: Bovine Spongiform Encephalopathy <[email protected]>
Sender: Bovine Spongiform Encephalopathy <[email protected]>
From: "Terry S. Singeltary Sr." <[email protected]>
Subject: Susceptibility of red deer (Cervus elaphus elaphus) to BSE

######## Bovine Spongiform Encephalopathy <[email protected]> #########

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TSE Project Details Project Ref M03024 Theme Risk assessment of SEs Sub Theme An evaluation of SEs transmission modalities from cattle to man and other food animals, environment vectors MRC Priority Title Susceptibility of red deer (Cervus elaphus elaphus) to BSE Funder(s) Principle Investigator Dr Hawkins PI Department Veterinary Laboratories Agency PI Location Weybridge PI Organisation Veterinary Laboratories Agency

Last Year Cost £ This Year Cost £ Start Date 01/04/2003 End Date 01/04/2010 Status Current Total Cost £ 1,485,458 Abstract The major cause of the spread of BSE was attributed to the feeding of contaminated meat and bone meal (MBM) in the protein rations fed to cattle. The use of MBM in animal feed was not restricted to cattle rations and it is known that MBM was included in the concentrates fed to farmed deer. BSE has been shown to be naturally or experimentally transmissible to a wide range of different ungulate species and deer are known to be susceptible to an endemic TSE (chronic wasting disease, CWD) which is prevalent in North America. However, to date, no TSE infections of UK deer have been reported. The initial objective of the study is to determine whether orally infected UK red deer are susceptible to bovine BSE agent. Groups of orally dosed deer will be sacrificed at 6, 12 and 60 months post inoculation and necropsies carried out. A range of tissue samples will be retained for further analysis such as immunohistochemistry. All animals will also be monitored clinically throughout the experiment to define any clinical phenotype.

©2004 Medical Research Council


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