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Notice to Members Regarding Chronic Wasting Disease (CWD)

Posted on: May 31st, 2017

To: MNA Members

From: Métis Nation of Alberta

Date: Wednesday, May 31, 2017

Métis Nation of Alberta (MNA) was made aware of a recent Canadian research study examining the transmission of Chronic Wasting Disease. The initial results of the study indicate that macaque monkeys (genetically similar to humans) can be infected with Chronic Wasting Disease (CWD) after eating deer that is infected with CWD. CWD is a prion disease, which are fatal, transmissible diseases characterized by abnormal proteins in the brain and nervous system. To date no research has shown that CWD can be passed on to humans, and no human cases of CWD have ever been identified. However, this new research indicates that it is a possibility. The Deputy Chief Medical Officer of Health has reached out to us to share with our Métis harvesters this important information.

For more information you can visit:

http://aep.alberta.ca/fish-wildlife...onic-wasting-disease/cwd-updates/default.aspx

and

www.nwhc.usgs.gov/disease_information/chronic_wasting_disease/index.jsp.

What the Alberta Government knows:
  • CWD is present in southeastern Alberta, with the area slowly spreading westward over time (introduced into Alberta from Saskatchewan) – see map for more information at http://aep.alberta.ca/fish-wildlife...uments/HuntersCWD-HarvestedDeerHeads-2016.pdf

  • CWD circulates in deer populations, particularly mule deer; it has been found in about 4% of deer tested in 2016;

  • Elk can be infected in areas where CWD has been present in deer for a long period of time;

  • Moose can also be infected, but this would be fairly rare.
Necessary Precautions for Harvesters:
  1. Hunters and others who handle carcasses follow basic handling precautions (available here http://aep.alberta.ca/fish-wildlife...DeerCarcassTransportationHandling-Oct2009.pdf
  2. All deer, moose and elk harvested from CWD mandatory submission wildlife management units (WMUs) be tested for CWD; and
  3. A negative result (no CWD detected by the test) must be obtained before any part of an animal is eaten.

For more information, contact:
Amy Quintal
Métis Nation of Alberta
Métis Harvesting Liaison
Tel: (780) 455 – 2200
[email protected]

http://albertametis.com/2017/05/notice-members-regarding-chronic-wasting-disease-cwd/

FRIDAY, JUNE 02, 2017

Alberta Canada Chronic Wasting Disease (CWD) Surveillance Update: 2016/17 Final

http://chronic-wasting-disease.blogspot.com/2017/06/alberta-canada-chronic-wasting-disease.html

Chronic Wasting Disease: CFIA Research Summary

Embargoed until May 23, 2017

(OCR of a scanned original)

Research Findings

Chronic Wasting Disease (CWD) is a progressive, fatal disease of the nervous system of cervids including deer, elk, moose, and reindeer that is caused by abnormal proteins called prions. It is known as a transmissible spongiform encephalopathy (TSE). Other TSEs include scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle, and Creutzfeldt-Jakob disease (CJD) in humans.
A limited number of experimental studies have demonstrated that non-human primates, specifically squirrel monkeys, are susceptible to CWD prions. An ongoing research study has now shown that CWD can also be transmitted to macaques, which are genetically closer to humans.
The study led by Dr. Stefanie Czub, a scientist at the Canadian Food Inspection Agency (CFIA), and funded by the Alberta Prion Research institute has demonstrated that by orally administering material under experimental conditions from cervids (deer and elk) naturally infected with CWD, the disease can be transmitted to macaques.

in this project, which began in 2009, 18 macaques were exposed to CWD in a variety of ways: by injecting into the brain, through contact with skin, oral administration, and intravenously (into the bloodstream through veins). So far, results are available from 5 animals. At this point, two animals that were exposed to CWD by direct introduction into the brain, one that was administered infected brain material by oral administration and two that were given infected muscle by oral administration have become infected with CWD. The study is ongoing and testing continues in the remaining animals. The early results will be presented at PRlON 2017, the annual international conference on prion diseases, in Edinburgh, Scotland, May 23 to 26, 2017.

Potential impacts of the new finding

Since 2003 Canada has a policy that recommends that animals and materials known to be infected with prions be removed from the food chain and from health products. Although no direct evidence of CWD prion transmission to humans has ever been recorded, the policy advocates a precautionary approach to managing CWD and potential human exposure to prions. These initial findings do not change Health Canada’s Health Products and Food Branch (HPFB) position on food and health products. A precautionary approach is still recommended to manage the potential risks of exposure to prions through food and health products. Measures are in place at federal, provincial and territorial levels to reduce human exposure to products potentially contaminated by CWD by preventing known infected animals from entering the marketplace.

While Federal and P/T government’s animal disease control policies continue to divert known CWD-infected animals away from entering the food and feed supply, research and development of sensitive detection methods including live-animal sampling techniques remain crucial for ensuring an accurate diagnosis. In addition, consistent federal, provincial and territorial communications of appropriate precautionary measures for hunters and indigenous communities are required.

Next Steps

The CFlA will continue to collaborate with national and international partners to develop and validate new diagnostic techniques. The CFlA will also continue to offer confirmatory testing services and reference laboratory expertise to provincial and territorial partners on demand.
Currently, CFlA laboratories are leading or collaborating on several research projects to understand the potential for CWD to infect humans. These projects use non‐human primates, genetically modified mice, and cell-free amplification approaches. Given the present findings, CFiA encourages continued research into TSEs.

The results of this study reinforce the need to redesign the federal program to foster greater adoption of risk mitigation measures for farmed cervids. Federal and provincial government collaboration will continue as new program options are assessed.

The results of Dr. Czub’s research into CWD will be of interest to scientists, governments, industry and people who consume cervid products. After the presentation at PRION 2017, the research will follow the normal steps of completion, peer review and publication. The Government of Canada will monitor the response to this research and determine whether further review of the science is required. Other studies underway by other researchers may also become public as a result of the presentation of Dr. Czub’s research.

The Public Health Agency of Canada, Health Canada, CFlA and other Federal partners are working together to assess what policies or programs need further review as well as preparing other communications about the research and health policy and advice to Canadian. 2017/04/28

===end...UNOFFICIAL...NO URL LINK...TSS===

0:30 First evidence of intracranial and peroral transmission of Chronic Wasting Disease (CWD) into Cynomolgus macaques: a work in progress

Dr Stefanie Czub University of Calgary Faculty of Veterinary Medicine/Canadian Food Inspection Agency Canada

http://prion2017.org/programme/

WEDNESDAY, MAY 03, 2017

*** First evidence of intracranial and peroral transmission of Chronic Wasting Disease (CWD) into Cynomolgus macaques

http://chronic-wasting-disease.blogspot.com/2017/05/first-evidence-of-intracranial-and.html

Wednesday, May 24, 2017

PRION2017 CONFERENCE VIDEO UPDATE 23 – 26 May 2017 Edinburgh UPDATE 1

Subject: PRION2017 CONFERENCE VIDEO UPDATE 23 – 26 May 2017 Edinburgh

*see archives of previous Prion Conferences, the ones that are still available, scroll down towards bottom in this link.

http://prionprp.blogspot.com/2017/05/prion2017-conference-video-update-23-26.html

WEDNESDAY, MAY 31, 2017

Texas New Exotic CWD Susceptible Species Rules Now in Effect

http://chronic-wasting-disease.blogspot.com/2017/05/texas-new-exotic-cwd-susceptible.html


with sad regards, terry
 

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I wouldn't get to excited about this just yet for a number of reasons.
The research has not been peer reviewed or published at this time. We don't have access to the methods or the findings. So as far as I can tell, we don't know if the researchers were just able to isolate the prions from monkey brains after ingestion. Or, if the prions led to clinical disease (symptomatic) in the animals?
Also, in comparison we can hypothesize that hundreds of thousands of humans have consumed prions from CWD infected deer. To date there is no evidence that the prions cause clinical disease in humans.
<----<<<
 

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Joe, imo, your wrong sir, there is evidence that cwd is a risk factor to humans and that it will look like sporadic cjd, 85% of all human tse prion, sporadic CJD...the studies above, part were from oral transmission to macaque of muscle tissue.

plus, if you look here ;

The association between venison eating and risk of CJD shows similar pattern, with regular venison eating associated with a 9 FOLD INCREASE IN RISK OF CJD (p = 0.04).

There is some evidence that risk of CJD INCREASES WITH INCREASING FREQUENCY OF LAMB EATING (p = 0.02).

The evidence for such an association between beef eating and CJD is weaker (p = 0.14). When only controls for whom a relative was interviewed are included, this evidence becomes a little STRONGER (p = 0.08).

snip...

It was found that when veal was included in the model with another exposure, the association between veal and CJD remained statistically significant (p = < 0.05 for all exposures), while the other exposures ceased to be statistically significant (p = > 0.05).

snip...

In conclusion, an analysis of dietary histories revealed statistical associations between various meats/animal products and INCREASED RISK OF CJD. When some account was taken of possible confounding, the association between VEAL EATING AND RISK OF CJD EMERGED AS THE STRONGEST OF THESE ASSOCIATIONS STATISTICALLY. ...

snip...

In the study in the USA, a range of foodstuffs were associated with an increased risk of CJD, including liver consumption which was associated with an apparent SIX-FOLD INCREASE IN THE RISK OF CJD. By comparing the data from 3 studies in relation to this particular dietary factor, the risk of liver consumption became non-significant with an odds ratio of 1.2 (PERSONAL COMMUNICATION, PROFESSOR A. HOFMAN. ERASMUS UNIVERSITY, ROTTERDAM). (???...TSS)

snip...see full report ;

http://collections.europarchive.org...einquiry.gov.uk/files/yb/1994/08/00004001.pdf


*** These results would seem to suggest that CWD does indeed have zoonotic potential, at least as judged by the compatibility of CWD prions and their human PrPC target. Furthermore, extrapolation from this simple in vitro assay suggests that if zoonotic CWD occurred, it would most likely effect those of the PRNP codon 129-MM genotype and that the PrPres type would be similar to that found in the most common subtype of sCJD (MM1).***


http://www.tandfonline.com/doi/full/10.4161/pri.28124?src=recsys

http://www.tandfonline.com/doi/pdf/10.4161/pri.28124?needAccess=true

The association between venison eating and risk of CJD shows similar pattern, with regular venison eating associated with a 9 FOLD INCREASE IN RISK OF CJD (p = 0.04).

There is some evidence that risk of CJD INCREASES WITH INCREASING FREQUENCY OF LAMB EATING (p = 0.02).

The evidence for such an association between beef eating and CJD is weaker (p = 0.14). When only controls for whom a relative was interviewed are included, this evidence becomes a little STRONGER (p = 0.08).

snip...

It was found that when veal was included in the model with another exposure, the association between veal and CJD remained statistically significant (p = < 0.05 for all exposures), while the other exposures ceased to be statistically significant (p = > 0.05).

snip...

In conclusion, an analysis of dietary histories revealed statistical associations between various meats/animal products and INCREASED RISK OF CJD. When some account was taken of possible confounding, the association between VEAL EATING AND RISK OF CJD EMERGED AS THE STRONGEST OF THESE ASSOCIATIONS STATISTICALLY. ...

snip...

In the study in the USA, a range of foodstuffs were associated with an increased risk of CJD, including liver consumption which was associated with an apparent SIX-FOLD INCREASE IN THE RISK OF CJD. By comparing the data from 3 studies in relation to this particular dietary factor, the risk of liver consumption became non-significant with an odds ratio of 1.2 (PERSONAL COMMUNICATION, PROFESSOR A. HOFMAN. ERASMUS UNIVERSITY, ROTTERDAM). (???...TSS)

snip...see full report ;

http://collections.europarchive.org...einquiry.gov.uk/files/yb/1994/08/00004001.pdf

you can see more evidence here ;

http://chronic-wasting-disease.blogspot.com/2016/05/zoonotic-potential-of-cwd-prions-update.html

really, i would not care what anyone eats. if you want to eat cwd infected deer elk or any cervid, that would be your risk to take, should not bother me. BUT, when it starts to risk my family, my children, friends, that have some sort of medical procedure done, surgery, dental, tissue, blood, etc. then that exposure of cwd to humans by consumption goes on to risk other humans that may never have eaten cervid. now is the time to act folks, we have floundered and pass this down the line long enough now it's catching up, and it may be too late. the incubation period here is what is fooling everyone. same thing happened with scrapie, until now, we know scrapie is risk to humans, this is scientific facts, ignore them if you must, but know this, you are playing with fire folks...don't take joe or my word on it. read the science, and then make you minds up if your gonna risk your loved ones with this. it's like playing russian roulette...

Research Article

Transmission of Creutzfeldt-Jakob disease to a chimpanzee by electrodes contaminated during neurosurgery.
FREE

  1. C J Gibbs, Jr,
  2. D M Asher,
  3. A Kobrine,
  4. H L Amyx,
  5. M P Sulima,
  6. D C Gajdusek
Author affiliations

Abstract
Stereotactic multicontact electrodes used to probe the cerebral cortex of a middle aged woman with progressive dementia were previously implicated in the accidental transmission of Creutzfeldt-Jakob disease (CJD) to two younger patients. The diagnoses of CJD have been confirmed for all three cases. More than two years after their last use in humans, after three cleanings and repeated sterilisation in ethanol and formaldehyde vapour, the electrodes were implanted in the cortex of a chimpanzee. Eighteen months later the animal became ill with CJD. This finding serves to re-emphasise the potential danger posed by reuse of instruments contaminated with the agents of spongiform encephalopathies, even after scrupulous attempts to clean them.

http://dx.doi.org/10.1136/jnnp.57.6.757

0:30 First evidence of intracranial and peroral transmission of Chronic Wasting Disease (CWD) into Cynomolgus macaques: a work in progress

Dr Stefanie Czub University of Calgary Faculty of Veterinary Medicine/Canadian Food Inspection Agency Canada

http://prion2017.org/programme/

''in this project, which began in 2009, 18 macaques were exposed to CWD in a variety of ways:

by injecting into the brain, through contact with skin, oral administration, and intravenously (into the bloodstream through veins).

So far, results are available from 5 animals.

At this point, two animals that were exposed to CWD by direct introduction into the brain,

one that was administered infected brain material by oral administration and

two that were given infected muscle by oral administration have become infected with CWD.

The study is ongoing and testing continues in the remaining animals. The early results will be presented at PRlON 2017, the annual international conference on prion diseases, in Edinburgh, Scotland, May 23 to 26, 2017.''

end...tss

i believe that CWD in cervids aka mad deer disease, and transmission there from to humans and other species, will be a greater risk factor than typical BSE in cattle aka mad cow disease, especially if cwd transmits to humans like cwd transmits to cervid. a frightening thought for sure. remember, incubation period can last decades, some say 50 years in some circumstances. it would be a damn shame for some to ignore these findings recently, go on to continue to ignore them, and then decades down the line a loved one came down with human tse there from.

it's up to each one of you to read the science to date, try and understand it, and then make your decision if you want you and your children and you family to consume cervid that might at risk of CWD TSE Prion...

kind regards, terry
 

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I wouldn't get to excited about this just yet for a number of reasons.
The research has not been peer reviewed or published at this time. We don't have access to the methods or the findings. So as far as I can tell, we don't know if the researchers were just able to isolate the prions from monkey brains after ingestion. Or, if the prions led to clinical disease (symptomatic) in the animals?
Also, in comparison we can hypothesize that hundreds of thousands of humans have consumed prions from CWD infected deer. To date there is no evidence that the prions cause clinical disease in humans.
<----<<<
There wasn't for bovine CWD either. Then in England......
 

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Terry, We already know that CJD infects humans. That is not the question.
So far we have no evidence that CWD is a threat to humans.
Did the monkeys in question develop clinical disease, or did the authors simply isolate the prions? That is my main question.
<----<<<
 

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Terry, We already know that CJD infects humans. That is not the question.
So far we have no evidence that CWD is a threat to humans.
Did the monkeys in question develop clinical disease, or did the authors simply isolate the prions? That is my main question.
<----<<<
''Three animals displayed signs of mild clinical disease, including anxiety, apathy, ataxia and/or tremor. In four animals wasting was observed, two of those had confirmed diabetes. All animals have variable signs of prion neuropathology in spinal cords and brains and by supersensitive IHC, reaction was detected in spinal cord segments of all animals.''

First evidence of intracranial and peroral transmission of Chronic Wasting Disease (CWD) into Cynomolgus macaques: a work in progress

Stefanie Czub1, Walter Schulz-Schaeffer2, Christiane Stahl-Hennig3, Michael Beekes4, Hermann Schaetzl5 and Dirk Motzkus6 1

University of Calgary Faculty of Veterinary Medicine/Canadian Food Inspection Agency; 2Universitatsklinikum des Saarlandes und Medizinische Fakultat der Universitat des Saarlandes; 3 Deutsches Primaten Zentrum/Goettingen; 4 Robert-Koch-Institut Berlin; 5 University of Calgary Faculty of Veterinary Medicine; 6 presently: Boehringer Ingelheim Veterinary Research Center; previously: Deutsches Primaten Zentrum/Goettingen

This is a progress report of a project which started in 2009. 21 cynomolgus macaques were challenged with characterized CWD material from white-tailed deer (WTD) or elk by intracerebral (ic), oral, and skin exposure routes. Additional blood transfusion experiments are supposed to assess the CWD contamination risk of human blood product. Challenge materials originated from symptomatic cervids for ic, skin scarification and partially per oral routes (WTD brain). Challenge material for feeding of muscle derived from preclinical WTD and from preclinical macaques for blood transfusion experiments. We have confirmed that the CWD challenge material contained at least two different CWD agents (brain material) as well as CWD prions in muscle-associated nerves.

Here we present first data on a group of animals either challenged ic with steel wires or per orally and sacrificed with incubation times ranging from 4.5 to 6.9 years at postmortem. Three animals displayed signs of mild clinical disease, including anxiety, apathy, ataxia and/or tremor. In four animals wasting was observed, two of those had confirmed diabetes. All animals have variable signs of prion neuropathology in spinal cords and brains and by supersensitive IHC, reaction was detected in spinal cord segments of all animals. Protein misfolding cyclic amplification (PMCA), real-time quaking-induced conversion (RT-QuiC) and PET-blot assays to further substantiate these findings are on the way, as well as bioassays in bank voles and transgenic mice.

At present, a total of 10 animals are sacrificed and read-outs are ongoing. Preclinical incubation of the remaining macaques covers a range from 6.4 to 7.10 years. Based on the species barrier and an incubation time of > 5 years for BSE in macaques and about 10 years for scrapie in macaques, we expected an onset of clinical disease beyond 6 years post inoculation.

PRION 2017 DECIPHERING NEURODEGENERATIVE DISORDERS

0:30 First evidence of intracranial and peroral transmission of Chronic Wasting Disease (CWD) into Cynomolgus macaques: a work in progress

Dr Stefanie Czub University of Calgary Faculty of Veterinary Medicine/Canadian Food Inspection Agency Canada

http://prion2017.org/programme/

see science to date that the call should be made NOW, that cwd to humans is possible, and all precautions there fore, should be take will great urgency.

WEDNESDAY, MAY 03, 2017

*** First evidence of intracranial and peroral transmission of Chronic Wasting Disease (CWD) into Cynomolgus macaques

http://chronic-wasting-disease.blogspot.com/2017/05/first-evidence-of-intracranial-and.html

WEDNESDAY, APRIL 05, 2017

Disease-associated prion protein detected in lymphoid tissues from pigs challenged with the agent of chronic wasting disease

http://chronic-wasting-disease.blogspot.com/2017/04/disease-associated-prion-protein.html

TUESDAY, APRIL 18, 2017

*** EXTREME USA FDA PART 589 TSE PRION FEED LOOP HOLE STILL EXIST, AND PRICE OF POKER GOES UP ***

http://usdameatexport.blogspot.com/2017/04/extreme-usa-fda-part-589-tse-prion-feed.html

TUESDAY, JUNE 06, 2017

CHRONIC WASTING DISEASE CWD TSE PRION ZOONOSIS ZOONOTIC INSIDIOUS AND DIRE CONSEQUENCES AHEAD

http://chronic-wasting-disease.blogspot.com/2017/06/chronic-wasting-disease-cwd-tse-prion.html

SATURDAY, JUNE 10, 2017

Chronic Wasting Disease CWD TSE Prion to Humans, who makes that final call, when, or, has it already happened?

http://chronic-wasting-disease.blogspot.com/2017/06/chronic-wasting-disease-cwd-tse-prion_10.html

MONDAY, JUNE 12, 2017

Rethinking Major grain organizations opposition to CFIA's control zone approach to Chronic Wasting CWD TSE Prion Mad Deer Type Disease 2017?

http://chronic-wasting-disease.blogspot.com/2017/06/rethinking-major-grain-organizations.html

Terry S. Singeltary Sr.
 

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Greetings Michigan Sportsman/women et al, i'm going to add some additional information for those of you that might still be interested in cwd tse prion and the data coming out of the PRION 2017 conference. i have not gone through all of it yet, but here is some of what i have gone through...

FRIDAY, JUNE 16, 2017

P55 Susceptibility of human prion protein to in vitro conversion by chronic wasting disease prions

http://chronic-wasting-disease.blogspot.com/2017/06/p55-susceptibility-of-human-prion.html

TUESDAY, JUNE 13, 2017

PRION 2017 CONFERENCE ABSTRACT Chronic Wasting Disease in European moose is associated with PrPSc features different from North American CWD

http://chronic-wasting-disease.blogspot.com/2017/06/prion-2017-conference-abstract-chronic.html

TUESDAY, JUNE 20, 2017

*** Norway Confirms 6th Case of Skrantesjuke CWD TSE Prion Disease ***

http://chronic-wasting-disease.blogspot.com/2017/06/norway-confirms-6th-case-of.html

TUESDAY, JUNE 20, 2017

Prion 2017 Conference Transmissible prions in the skin of Creutzfeldt-Jakob disease patients

http://creutzfeldt-jakob-disease.blogspot.com/2017/06/prion-2017-conference-transmissible.html

MONDAY, JUNE 19, 2017

PRION 2017 P20 Descriptive epidemiology of human prion diseases in Japan: a prospective 16-year surveillance study

Japan Prion Disease Increasing Annually to 2.3 patients per 1 million populations in 2014

http://creutzfeldt-jakob-disease.blogspot.com/2017/06/prion-2017-p20-descriptive-epidemiology.html

Saturday, June 17, 2017

PRION 2017 P115 α- Synuclein prions from MSA patients exhibit similar transmission properties as PrPSc prions

http://msaprion.blogspot.com/2017/06/prion-2017-p115-synuclein-prions-from.html

TUESDAY, JUNE 13, 2017

PRION 2017 CONFERENCE ABSTRACT First evidence of intracranial and peroral transmission of Chronic Wasting Disease (CWD) into Cynomolgus macaques: a work in progress

http://chronic-wasting-disease.blogspot.com/2017/06/prion-2017-conference-abstract-first.html

kind regards, terry
 

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Thanks for the update, Terry. Hopefully this don't turn into a mad BSE type problem like England had.

Unfortunately here in Michigan the MDNR is caught between disease control and appeasing the trophy hunter special interest's....much like Wisconsin.
 
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