The Stevens M-200 with a TT scope and hand loads of 75 Speer HP and IMR-4895 make that shooting no problem. The 243 shoots just fine out there and it doesnt have the drift of the 22 cals. [Speer manual states that for those who didnt know]. However we do use a lot of 22-250 ammo, and 25-06 75gr HP/over AA-3100 powder.Rupestris said:Really depends on what you'll be shooting. For varmints I'd probably zero @ 200yards with additional info taped to the stock regarding longer shots (ammo, elevation & distance). That way you have some idea of how many "clicks" you'll need to adjust when that 500 yard shot presents itself.
Most "500 yard club" folks are using rifles a little higher-end and many are either using flat shooting rounds like .22-250 or wildcat rounds. Handloading and tuning rounds for your particular rifle would help as well.
For deer, I'd stick to 100gr. and shorter distances. Maybe 200yd max.