Chronic wasting disease in a Wisconsin white-tailed deer farm September 1 2008

Discussion in 'Whitetail Deer Disease' started by terry, Sep 6, 2008.

  1. terry

    terry Banned

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    Contents: September 1 2008, Volume 20, Issue 5

    Journal of Veterinary Diagnostic Investigation Vol. 20 Issue 5, 698-703 Copyright © 2008 by the American Association of Veterinary Laboratory Diagnosticians

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    Case Reports

    Chronic wasting disease in a Wisconsin white-tailed deer farm

    Delwyn P. Keane1, Daniel J. Barr, Philip N. Bochsler, S. Mark Hall, Thomas Gidlewski, Katherine I. O'Rourke, Terry R. Spraker and Michael D. Samuel Correspondence: 1Corresponding Author: Delwyn Keane, University of Wisconsin, Wisconsin Veterinary Diagnostic Laboratory, 445 Easterday Lane, Madison, WI 53706. [email protected]

    In September 2002, chronic wasting disease (CWD), a prion disorder of captive and wild cervids, was diagnosed in a white-tailed deer (Odocoileus virginianus) from a captive farm in Wisconsin. The facility was subsequently quarantined, and in January 2006 the remaining 76 deer were depopulated. Sixty animals (79%) were found to be positive by immunohistochemical staining for the abnormal prion protein (PrPCWD) in at least one tissue; the prevalence of positive staining was high even in young deer. Although none of the deer displayed clinical signs suggestive of CWD at depopulation, 49 deer had considerable accumulation of the abnormal prion in the medulla at the level of the obex. Extraneural accumulation of the abnormal protein was observed in 59 deer, with accumulation in the retropharyngeal lymph node in 58 of 59 (98%), in the tonsil in 56 of 59 (95%), and in the rectal mucosal lymphoid tissue in 48 of 58 (83%). The retina was positive in 4 deer, all with marked accumulation of prion in the obex. One deer was considered positive for PrPCWD in the brain but not in the extraneural tissue, a novel observation in white-tailed deer. The infection rate in captive deer was 20-fold higher than in wild deer. Although weakly related to infection rates in extraneural tissues, prion genotype was strongly linked to progression of prion accumulation in the obex. Antemortem testing by biopsy of recto–anal mucosal-associated lymphoid tissue (or other peripheral lymphoid tissue) may be a useful adjunct to tonsil biopsy for surveillance in captive herds at risk for CWD infection.

    http://jvdi.org/cgi/content/abstrac...TINDEX=0&volume=20&issue=5&resourcetype=HWCIT


    PLEASE NOTE 76 DEER WERE DEPOPULATED. SIXTY ANIMALS (79%) WERE FOUND TO BE POSITIVE BY IMMUNOHISTOCHEMICAL STAINING FOR THE ABNORMAL PRION PROTEIN (PrPCWD) IN AT LEAST ONE TISSUE; THE PREVALENCE OF POSITIVE STAINING WAS HIGH IN YOUNG DEER. ...TSS


    Saturday, September 06, 2008
    Chronic wasting disease in a Wisconsin white-tailed deer farm 79% INFECTION RATE

    http://chronic-wasting-disease.blogspot.com/2008/09/chronic-wasting-disease-in-wisconsin.html


    TSS
     
  2. 8nchuck

    8nchuck

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    ???? They found it one in 2002 and then killed the rest in 2006, 4 years later?

    Anyways it is a report on an old case.
     

  3. traditional

    traditional

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    It does show what can happen in 4 years if nothing is done to contain the disease.
     
  4. ridgewalker

    ridgewalker

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    I'll buy that but exactly what was the means of transmission? Can all those fancy scientific terms be boiled down into layman's terms? I keep hearing the word prion but exactly what is it> a virus, spore, germ, infectious agent, etc. Do I understand correctly that it is some sort of antagonist for cwd? I am not a biochemist so a lot of this become somewhat difficult to sort out.