Chronic Wasting Disease CWD TSE Prion RoundUp February 18, 2018

Discussion in 'Wildlife Diseases' started by terry, Feb 18, 2018.

  1. bioactive

    bioactive Tornado Jim Premium Member

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    fishinfanatic19 and otcarcher like this.
  2. otcarcher

    otcarcher Banned

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    Yep. I posted the same a few posts ago. There are 100's more examples out there of the same nonsense.
     

  3. Liver and Onions

    Liver and Onions

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    Terry, could you post your credentials ?

    L & O
     
  4. otcarcher

    otcarcher Banned

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    Terry Singletary — A retired machinist and high school dropout, Terry Singletary suffered the tragic loss of his mother to “sporadic” Creutzfeldt-Jakob disease (CJD) in 1997. Desperate to find an explanation for his mother’s death, he has devoted himself to the sad and fruitless task of connecting her death to her diet. Various reports confirm that Mrs. Singletary’s life was claimed by the most common sub-type of CJD (one that accounts for 70 percent of “sporadic” cases). Sporadic CJD, unlike its newer “variant,” is not linked to meat.
    As the self-appointed international coordinator of CJD Watch, an organization he co-founded with social worker Deborah Oney, Singletary is cited in media reports as an apparent expert on tracking mad cow disease. This despite his lack of formal education and the absence for support from any credible academic, medical or scientific authority. His sensationalist allegations about the safety of U.S. beef have found their way into hundreds of newspapers and broadcasts. Singletary moderates a mad-cow discussion forum run by a vegetarian activist group; his contributions account for more than half the traffic on the “BSE-L” mailing list, which is generally read by real scientists. Animal rights activists and other food-scare artists frequently refer to him as “Dr. Terry Singletary,” apparently an honorary degree as he has yet to finish high school.
    Like many activists, Singletary ignores overwhelming epidemiological and laboratory evidence that rules out a connection between sporadic CJD and beef. Relying entirely on shallow circumstantial evidence and frequent repetition of claims which have been publicly refuted as false, he also blindly insists upon a mad-cow with Alzheimer’s, Parkinson’s, and Lou Gehrig’s disease. His specific allegations have been clearly refuted by Centers for Disease Countrol and Prevention scientists in the journalNeurology


    Hope this helps with your questions about Terry the "Flounder"

    https://iowawhitetail.com/forum/thr...-prions-cwd-not-good-for-hunters.49504/page-2
     
    Last edited: Mar 1, 2018
  5. otcarcher

    otcarcher Banned

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    Another comment about Terry from a forum in New York.....

    "Ill do some reading, but at first skim through, his blog is full of PETA back patting and all kinds of things that raise my eyebrow."
     
  6. otcarcher

    otcarcher Banned

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    The bottom line......
    These links are being shared ad nauseum in multiple forums across the country by a fear-mongering anti-meat zealot, who is a high school dropout retired machinist with absolutely no formal college education or experience in this field of study.
     
  7. terry

    terry Banned

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    Jim, dr. Brauker, or bioactive, and otcarcher et al, you are really showing your ignorance with your lack of knowledge about the CWD TSE Prion, especially if this is all you captive game farmers et al have. very sad, and very possible, very dangerous for the folks you do business with...

    Posted On December 20, 2003

    AFTER THE FIRST CASE OF MAD COW DISEASE IN THE USA WAS DOCUMENTED

    " Like many activists, Singletary ignores overwhelming epidemiological and laboratory evidence that rules out a connection between sporadic CJD and beef. Relying entirely on shallow circumstantial evidence and frequent repetition of claims which have been publicly refuted as false, he also blindly insists upon a mad-cow with Alzheimer’s, Parkinson’s, and Lou Gehrig’s disease. "

    http://www.consumerfreedom.com/article_detail.cfm/a/138-mad-cow-scaremongers

    SO, just who are The Center for Consumer Freedom ;

    http://www.consumerfreedom.com/index.cfm

    let's take a closer look shall we ;

    The Center for Consumer Freedom (CCF) (formerly called the "Guest Choice Network (GCN)") is a front group for the restaurant, alcohol and tobacco industries. It runs media campaigns which oppose the efforts of scientists, doctors, health advocates, environmentalists and groups like Mothers Against Drunk Driving, calling them "the Nanny Culture -- the growing fraternity of food cops, health care enforcers, anti-meat activists, and meddling bureaucrats who 'know what's best for you.'"

    CCF is registered as a tax-exempt, non-profit organization under the IRS code 501(c)(3). Its advisory board is comprised mainly of representatives from the restaurant, meat and alcoholic beverage industries.

    http://www.sourcewatch.org/index.php?title=Center_for_Consumer_Freedom

    http://en.wikipedia.org/wiki/Center_for_Consumer_Freedom

    SNIP...SEE FULL TEXT AND MORE HERE

    http://transmissiblespongiformencephalopathy.blogspot.com/2011/09/mad-cow-scaremongers.html

    http://betaamyloidcjd.blogspot.com/2010/12/alimentary-prion-infections-touch-down.html

    http://madcowusda.blogspot.com/2014/09/mad-cow-scaremongers-consumerfreedomcom.html

    NOW, let’s review the TSE prion aka mad cow type disease science to date, since this consumerfreedom.com article was published in December of 2003, shall we...

    PRION CONFERENCE 2015, 2016, 2017, ON potential for CWD TSE PRION ZOONOSIS, if it has not happened already...

    O.05: Transmission of prions to primates after extended silent incubation periods: Implications for BSE and scrapie risk assessment in human populations Emmanuel Comoy, Jacqueline Mikol, Valerie Durand, Sophie Luccantoni, Evelyne Correia, Nathalie Lescoutra, Capucine Dehen, and Jean-Philippe Deslys Atomic Energy Commission; Fontenay-aux-Roses, France Prion diseases (PD) are the unique neurodegenerative proteinopathies reputed to be transmissible under field conditions since decades. The transmission of Bovine Spongiform Encephalopathy (BSE) to humans evidenced that an animal PD might be zoonotic under appropriate conditions. Contrarily, in the absence of obvious (epidemiological or experimental) elements supporting a transmission or genetic predispositions, PD, like the other proteinopathies, are reputed to occur spontaneously (atpical animal prion strains, sporadic CJD summing 80% of human prion cases). Non-human primate models provided the first evidences supporting the transmissibiity of human prion strains and the zoonotic potential of BSE. Among them, cynomolgus macaques brought major information for BSE risk assessment for human health (Chen, 2014), according to their phylogenetic proximity to humans and extended lifetime. We used this model to assess the zoonotic potential of other animal PD from bovine, ovine and cervid origins even after very long silent incubation periods.

    *** We recently observed the direct transmission of a natural classical scrapie isolate to macaque after a 10-year silent incubation period,

    ***with features similar to some reported for human cases of sporadic CJD, albeit requiring fourfold long incubation than BSE. Scrapie, as recently evoked in humanized mice (Cassard, 2014),

    ***is the third potentially zoonotic PD (with BSE and L-type BSE),

    ***thus questioning the origin of human sporadic cases.

    We will present an updated panorama of our different transmission studies and discuss the implications of such extended incubation periods on risk assessment of animal PD for human health.
    ===============
    ***thus questioning the origin of human sporadic cases***
    ===============
    ***our findings suggest that possible transmission risk of H-type BSE to sheep and human. Bioassay will be required to determine whether the PMCA products are infectious to these animals.
    ==============

    https://prion2015.files.wordpress.com/2015/05/prion2015abstracts.pdf

    PRION 2016 TOKYO

    Saturday, April 23, 2016

    SCRAPIE WS-01: Prion diseases in animals and zoonotic potential 2016

    Prion. 10:S15-S21. 2016 ISSN: 1933-6896 printl 1933-690X online

    Taylor & Francis

    Prion 2016 Animal Prion Disease Workshop Abstracts

    WS-01: Prion diseases in animals and zoonotic potential

    Transmission data also revealed that several scrapie prions propagate in HuPrP-Tg mice with efficiency comparable to that of cattle BSE. While the efficiency of transmission at primary passage was low, subsequent passages resulted in a highly virulent prion disease in both Met129 and Val129 mice.
    Transmission of the different scrapie isolates in these mice leads to the emergence of prion strain phenotypes that showed similar characteristics to those displayed by MM1 or VV2 sCJD prion.

    These results demonstrate that scrapie prions have a zoonotic potential and raise new questions about the possible link between animal and human prions.

    http://www.tandfonline.com/doi/abs/10.1080/19336896.2016.1163048?journalCode=kprn20

    why do we not want to do TSE transmission studies on chimpanzees $

    5. A positive result from a chimpanzee challenged severly would likely create alarm in some circles even if the result could not be interpreted for man. I have a view that all these agents could be transmitted provided a large enough dose by appropriate routes was given and the animals kept long enough. Until the mechanisms of the species barrier are more clearly understood it might be best to retain that hypothesis.

    snip...

    R. BRADLEY

    https://web.archive.org/web/2017012...einquiry.gov.uk/files/yb/1990/09/23001001.pdf

    Title: Transmission of scrapie prions to primate after an extended silent incubation period)

    *** In complement to the recent demonstration that humanized mice are susceptible to scrapie, we report here the first observation of direct transmission of a natural classical scrapie isolate to a macaque after a 10-year incubation period. Neuropathologic examination revealed all of the features of a prion disease: spongiform change, neuronal loss, and accumulation of PrPres throughout the CNS.

    *** This observation strengthens the questioning of the harmlessness of scrapie to humans, at a time when protective measures for human and animal health are being dismantled and reduced as c-BSE is considered controlled and being eradicated.

    *** Our results underscore the importance of precautionary and protective measures and the necessity for long-term experimental transmission studies to assess the zoonotic potential of other animal prion strains.

    http://www.ars.usda.gov/research/publications/publications.htm?SEQ_NO_115=313160
     
  8. otcarcher

    otcarcher Banned

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    And just like in Texas, Iowa, New York, and elsewhere....Terry continues the anti-meat, anti-hunting, PETA agenda by calling those who call him out for exactly who he is as "Captive Game Farmers". We are not, nor are we apologetic to them. It's time for you and PETA to stop the fear-mongering here.
     
  9. terry

    terry Banned

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    Continued part two...

    *** WDA 2016 NEW YORK ***

    *** We found that CWD adapts to a new host more readily than BSE and that human PrP was unexpectedly prone to misfolding by CWD prions. In addition, we investigated the role of specific regions of the bovine, deer and human PrP protein in resistance to conversion by prions from another species. We have concluded that the human protein has a region that confers unusual susceptibility to conversion by CWD prions.

    Wildlife Disease Risk Communication Research Contributes to Wildlife Trust Administration Exploring perceptions about chronic wasting disease risks among wildlife and agriculture professionals and stakeholders

    http://www.wda2016.org/uploads/5/8/6/1/58613359/wda_2016_conference_proceedings_low_res.pdf

    Prion 2017 Conference Abstracts CWD

    2017 PRION CONFERENCE

    First evidence of intracranial and peroral transmission of Chronic Wasting Disease (CWD) into Cynomolgus macaques: a work in progress

    Stefanie Czub1, Walter Schulz-Schaeffer2, Christiane Stahl-Hennig3, Michael Beekes4, Hermann Schaetzl5 and Dirk Motzkus6 1
    University of Calgary Faculty of Veterinary Medicine/Canadian Food Inspection Agency; 2Universitatsklinikum des Saarlandes und Medizinische Fakultat der Universitat des Saarlandes; 3 Deutsches Primaten Zentrum/Goettingen; 4 Robert-Koch-Institut Berlin; 5 University of Calgary Faculty of Veterinary Medicine; 6 presently: Boehringer Ingelheim Veterinary Research Center; previously: Deutsches Primaten Zentrum/Goettingen

    This is a progress report of a project which started in 2009. 21 cynomolgus macaques were challenged with characterized CWD material from white-tailed deer (WTD) or elk by intracerebral (ic), oral, and skin exposure routes. Additional blood transfusion experiments are supposed to assess the CWD contamination risk of human blood product. Challenge materials originated from symptomatic cervids for ic, skin scarification and partially per oral routes (WTD brain). Challenge material for feeding of muscle derived from preclinical WTD and from preclinical macaques for blood transfusion experiments. We have confirmed that the CWD challenge material contained at least two different CWD agents (brain material) as well as CWD prions in muscle-associated nerves.

    Here we present first data on a group of animals either challenged ic with steel wires or per orally and sacrificed with incubation times ranging from 4.5 to 6.9 years at postmortem. Three animals displayed signs of mild clinical disease, including anxiety, apathy, ataxia and/or tremor. In four animals wasting was observed, two of those had confirmed diabetes. All animals have variable signs of prion neuropathology in spinal cords and brains and by supersensitive IHC, reaction was detected in spinal cord segments of all animals. Protein misfolding cyclic amplification (PMCA), real-time quaking-induced conversion (RT-QuiC) and PET-blot assays to further substantiate these findings are on the way, as well as bioassays in bank voles and transgenic mice.

    At present, a total of 10 animals are sacrificed and read-outs are ongoing. Preclinical incubation of the remaining macaques covers a range from 6.4 to 7.10 years. Based on the species barrier and an incubation time of > 5 years for BSE in macaques and about 10 years for scrapie in macaques, we expected an onset of clinical disease beyond 6 years post inoculation.


    PRION 2017 CONFERENCE DECIPHERING NEURODEGENERATIVE DISORDERS

    *** PRION 2017 CONFERENCE VIDEO


    http://prion2017.org/programme/

    TUESDAY, JUNE 13, 2017

    PRION 2017 CONFERENCE ABSTRACT

    First evidence of intracranial and peroral transmission of Chronic Wasting Disease (CWD) into Cynomolgus macaques: a work in progress

    http://chronic-wasting-disease.blogspot.com/2017/06/prion-2017-conference-abstract-first.html

    TUESDAY, JULY 04, 2017

    *** PRION 2017 CONFERENCE ABSTRACTS ON CHRONIC WASTING DISEASE CWD TSE PRION ***

    http://chronic-wasting-disease.blogspot.com/2017/07/prion-2017-conference-abstracts-on.html

    ***Moreover, sporadic disease has never been observed in breeding colonies or primate research laboratories, most notably among hundreds of animals over several decades of study at the National Institutes of Health25, and in nearly twenty older animals continuously housed in our own facility.***

    http://www.nature.com/articles/srep11573

    SATURDAY, JULY 29, 2017

    Risk Advisory Opinion: Potential Human Health Risks from Chronic Wasting Disease CFIA, PHAC, HC (HPFB and FNIHB), INAC, Parks Canada, ECCC and AAFC

    http://chronic-wasting-disease.blogspot.com/2017/07/risk-advisory-opinion-potential-human.html

    > However, to date, no CWD infections have been reported in people.

    key word here is 'reported'. science has shown that CWD in humans will look like sporadic CJD. SO, how can one assume that CWD has not already transmitted to humans? they can't, and it's as simple as that. from all recorded science to date, CWD has already transmitted to humans, and it's being misdiagnosed as sporadic CJD. ...terry

    LOOKING FOR CWD IN HUMANS AS nvCJD or as an ATYPICAL CJD, LOOKING IN ALL THE WRONG PLACES $$$

    *** These results would seem to suggest that CWD does indeed have zoonotic potential, at least as judged by the compatibility of CWD prions and their human PrPC target. Furthermore, extrapolation from this simple in vitro assay suggests that if zoonotic CWD occurred, it would most likely effect those of the PRNP codon 129-MM genotype and that the PrPres type would be similar to that found in the most common subtype of sCJD (MM1).***

    http://www.tandfonline.com/doi/full/10.4161/pri.28124?src=

    http://www.tandfonline.com/doi/pdf/10.4161/pri.28124?needAccess=true

    http://wwwnc.cdc.gov/eid/article/20/1/13-0858_article.

    TUESDAY, SEPTEMBER 12, 2017

    CDC Now Recommends Strongly consider having the deer or elk tested for CWD before you eat the meat

    http://chronic-wasting-disease.blogspot.com/2017/09/cdc-now-recommends-strongly-consider.html

    SATURDAY, JANUARY 27, 2018

    CDC CHRONIC WASTING DISEASE CWD TSE PRION UPDATE REPORT USA JANUARY 2018

    http://chronic-wasting-disease.blogspot.com/2018/01/cdc-chronic-wasting-disease-cwd-tse.html

    Sunday, February 25, 2018

    PRION ROUND TABLE CONFERENCE 2018 MAY, 22-25 A REVIEW

    http://prionconference.blogspot.com/2018/02/prion-round-table-conference-2018-may.html
     
  10. otcarcher

    otcarcher Banned

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  11. terry

    terry Banned

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    Alzheimer’s disease, iatrogenic, and Transmissible Spongiform Encephalopathy TSE Prion disease, that is the question ???

    >>> The only tenable public line will be that "more research is required’’ <<<

    >>> possibility on a transmissible prion remains open<<<

    O.K., so it’s about 23 years later, so somebody please tell me, when is "more research is required’’ enough time for evaluation ?

    [9. Whilst this matter is not at the moment directly concerned with the iatrogenic CJD cases from hgH, there remains a possibility of litigation here, and this presents an added complication. There are also results to be made available shortly (1) concerning a farmer with CJD who had BSE animals, (2) on the possible transmissibility of Alzheimer’s and (3) a CMO letter on prevention of iatrogenic CJD transmission in neurosurgery, all of which will serve to increase media interest.]

    https://web.archive.org/web/2017012...einquiry.gov.uk/files/yb/1992/11/04001001.pdf

    https://web.archive.org/web/2004031...einquiry.gov.uk/files/yb/1992/12/16005001.pdf

    https://web.archive.org/web/20040315075058/www.bseinquiry.gov.uk/files/yb/1992/12/16005001.pdf

    snip...see full Singeltary Nature comment here;

    http://www.nature.com/nature/journal/v525/n7568/full/nature15369.html#/comments

    see Singeltary comments to Plos ;

    Alzheimer's disease

    let's not forget the elephant in the room. curing Alzheimer's would be a great and wonderful thing, but for starters, why not start with the obvious, lets prove the cause or causes, and then start to stop that. think iatrogenic, friendly fire, or the pass it forward mode of transmission. think medical, surgical, dental, tissue, blood, related transmission. think transmissible spongiform encephalopathy aka tse prion disease aka mad cow type disease...

    Commentary: Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

    http://journals.plos.org/plosone/article/comment?id=info:do I/10.1371/annotation/933cc83a-a384-45c3-b3b2-336882c30f9d
    https://www.frontiersin.org/articles/10.3389/fnagi.2016.00005/full

    Self-Propagative Replication of Ab Oligomers Suggests Potential Transmissibility in Alzheimer Disease

    *** Singeltary comment PLoS ***

    Alzheimer’s disease and Transmissible Spongiform Encephalopathy prion disease, Iatrogenic, what if ?

    Posted by flounder on 05 Nov 2014 at 21:27 GMT

    http://www.plosone.org/annotation/listThread.action?root=82860

    Tuesday, December 12, 2017

    Neuropathology of iatrogenic Creutzfeldt–Jakob disease and immunoassay of French cadaver-sourced growth hormone batches suggest possible transmission of tauopathy and long incubation periods for the transmission of Abeta pathology

    http://tauopathies.blogspot.com/2017/12/neuropathology-of-iatrogenic.html

    PRION Conference Roundtable 2018

    http://prionconference.blogspot.com/

    Terry
     
  12. otcarcher

    otcarcher Banned

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    Terry Singletary — A retired machinist and high school dropout, Terry Singletary suffered the tragic loss of his mother to “sporadic” Creutzfeldt-Jakob disease (CJD) in 1997. Desperate to find an explanation for his mother’s death, he has devoted himself to the sad and fruitless task of connecting her death to her diet. Various reports confirm that Mrs. Singletary’s life was claimed by the most common sub-type of CJD (one that accounts for 70 percent of “sporadic” cases). Sporadic CJD, unlike its newer “variant,” is not linked to meat.

    As the self-appointed international coordinator of CJD Watch, an organization he co-founded with social worker Deborah Oney, Singletary is cited in media reports as an apparent expert on tracking mad cow disease. This despite his lack of formal education and the absence for support from any credible academic, medical or scientific authority. His sensationalist allegations about the safety of U.S. beef have found their way into hundreds of newspapers and broadcasts. Singletary moderates a mad-cow discussion forum run by a vegetarian activist group; his contributions account for more than half the traffic on the “BSE-L” mailing list, which is generally read by real scientists. Animal rights activists and other food-scare artists frequently refer to him as “Dr. Terry Singletary,” apparently an honorary degree as he has yet to finish high school.

    Like many activists, Singletary ignores overwhelming epidemiological and laboratory evidence that rules out a connection between sporadic CJD and beef. Relying entirely on shallow circumstantial evidence and frequent repetition of claims which have been publicly refuted as false, he also blindly insists upon a mad-cow with Alzheimer’s, Parkinson’s, and Lou Gehrig’s disease. His specific allegations have been clearly refuted by Centers for Disease Countrol and Prevention scientists in the journal Neurology.
     
  13. Rainman68

    Rainman68

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    I Googled Terry and found this.

    Guinness World Records - Most copy and pastes in a hunting forum thread - Terry Singletary 2018.
     
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  14. Lily Furina

    Lily Furina Banned

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    https://www.avma.org/News/JAVMANews/Pages/061201j.aspx

    Study: chronic wasting disease spread through blood, saliva, blood-feeding insects – Ticks!

    Chronic wasting disease might be passed in the blood and saliva of infected deer, according to a Colorado State University-led study published in the Oct. 6 edition of Science.

    Researchers say the findings raise new questions about whether the disease can be spread by blood-sucking insects or social contact between animals. Moreover, the evidence suggests that no tissue from an infected animal can be considered free of disease-causing prions.

    Chronic wasting disease is a degenerative brain disease in cervids characterized by weight loss leading to death. It was discovered in 1967 in mule deer at a wildlife research facility in Colorado. Today, CWD has been found in free-ranging and captive deer and elk in 14 states and two Canadian provinces.

    The research team tested the blood, saliva, feces, and urine of CWD-infected deer to determine how the disease is passed between animals. Infectious prions were discovered in the animals' tonsils as soon as three months after exposure to saliva or blood from an infected deer.

    Scientists have been at a loss as to how animals were infecting one another with the fatal disease agent. "This study shows for the first time that CWD can be passed to deer that come into contact with the blood and saliva of infected deer," said study leader, Dr. Edward A. Hoover, a CSU Distinguished Professor in the Department of Microbiology.

    Grooming, licking, and nuzzling are important social interactions among deer and elk—behaviors that are accompanied by salivary exchange.

    Although there are no known cases of CWD transmission to humans, people should avoid bodily fluids from CWD and other prion infections, Dr. Hoover said. "The study also causes us to reconsider a potential role for blood-feeding insects such as mosquitoes and ticks in the transmission of CWD or other prion infections," he added.

    ---

    The widespread tick population explosion coincides with the spred of CWD-INFECTED animals.

    Of course we all know that the massive tick populaiton is due the the invasion of the coyotes and the demise of the fox. Unless steps are taking to reduce the populaiton of coyotes our deer hunting will soon come to an end.
     
  15. otcarcher

    otcarcher Banned

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    Who are you trying to kid Terry? Just couldn't stay away could you? Losing ground with your fear-mongering blog?
     
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